Brand  (β version)

PDB ID: 3HPS

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Ligands
Code Name Style Show Link
COI 2-oxo-4-methylpentanoic acid PoSSuM
GOL Glycerol PoSSuM
LEU Leucine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3HPS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)
Release Data : 2010-05-19
Compound :
mol_id molecule chains synonym
1 2-isopropylmalate synthase A,B Alpha-isopropylmalate synthase, Alpha-IPM synthetase
ec: 2.3.3.13
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli  (taxid:562)
strain: H37Rv
atcc: 25618
gene: leuA, MT3813, MTV025.058, Rv3710
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pPROEXHTa
Authors : Koon, N., Squire, C.J., Baker, E.N.
Keywords : 2-isopropylmalate synthase, LeuA, Mycobacterium tuberculosis, leucine biosynthesis, enzyme, TIM barrel, regulatory domain, substrate, Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Probing the active site of M. tuberculosis LeuA

Koon, N.,Squire, C.J.,Baker, E.N.
To be Published 

Reaction

Chain : A, B
UniProt : P96420
Reaction : -