Brand  (β version)

PDB ID: 3HP9

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Ligands
Code Name Style Show Link
CF1 2-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-5-methoxybenzoic acid PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3HP9   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of SSB/Exonuclease I in complex with inhibitor CFAM
Release Data : 2010-01-19
Compound :
mol_id molecule chains synonym
1 Exodeoxyribonuclease I A Exonuclease I, DNA deoxyribophosphodiesterase, dRPase
ec: 3.1.11.1
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K-12
gene: b2011, cpeA, JW1993, sbcB, xonA
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET
Authors : Satyshur, K.A.
Keywords : EXONUCLEASE, SSB, GENOME MAINTENANCE, DNA DAMAGE, DNA REPAIR, HYDROLASE, NUCLEASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance

Lu, D.,Bernstein, D.A.,Satyshur, K.A.  et al.
(2010)  Proc.Natl.Acad.Sci.USA  107 : 633 - 638

PubMed: 20018747
DOI: 10.1073/pnas.0909191107

Reaction

Chain : A
UniProt : P04995 (EX1_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. 3.1.11.1 PubMed:18591666, PubMed:20018747, PubMed:23609540
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:18219121
ECO:0000269 | PubMed:18591666
ECO:0000269 | PubMed:20018747
ECO:0000269 | PubMed:23609540
Binds 2 Mg(2+) ions per monomer.