Brand  (β version)

PDB ID: 3HMP

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Ligands
Code Name Style Show Link
CX4 7-chloro-N-(cyclopropylmethyl)quinazolin-4-amine PoSSuM
7PE 2-(2-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
GOL Glycerol PoSSuM
IPA Isopropyl alcohol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HMP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human Mps1 catalytic domain in complex with a quinazolin ligand Compound 4
Release Data : 2010-02-02
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase TTK A Phosphotyrosine picked threonine-protein kinase, PYT
ec: 2.7.12.1
fragment: CATALYTIC DOMAIN, residues 510-809
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MPS1L1, TTK
expression_system_strain: BL21(DE3)LysS
expression_system_vector_type: PLASMID
expression_system_plasmid: pET30
Authors : Chu, M.L.H., Chavas, L.M.G., Williams, D.H., Tabernero, L., Eyers, P.A.
Keywords : MPS1, TTK, CX4, KINASE, ATP-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Tyrosine-protein kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.

Chu, M.L.,Lang, Z.,Chavas, L.M.  et al.
(2010)  Biochemistry  49 : 1689 - 1701

PubMed: 20099905
DOI: 10.1021/bi901970c

Reaction

Chain : A
UniProt : P33981 (TTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.1 PubMed:30785839, PubMed:29162720
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:29162720
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:29162720
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