Brand  (β version)

PDB ID: 3HMJ

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Ligands
Code Name Style Show Link
CER (2s, 3r)-3-hydroxy-4-oxo-7,10-trans,trans-dodecadienamide PoSSuM
FMN Flavin mononucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HMJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Saccharomyces cerevisiae FAS type I
Release Data : 2009-09-01
Compound :
mol_id molecule chains
1 Fatty acid synthase subunit alpha A,B,C
ec: 2.3.1.86
mol_id molecule chains
2 Fatty acid synthase subunit beta G,H,I
ec: 2.3.1.86
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
gene: FAS2
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
gene: FAS1
Authors : Johansson, P., Mulinacci, B., Koestler, C., Vollrath, R., Oesterhelt, D., Grininger, M.
Keywords : FAS, PPT, phosphopantetheine transferase, fatty acid, multienyzme, Fatty acid biosynthesis, Lipid synthesis, Multifunctional enzyme, NAD, NADP, Oxidoreductase, Phosphoprotein, Hydrolase, Lyase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 4.000 Å )
Citation :

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase

Johansson, P.,Mulinacci, B.,Koestler, C.  et al.
(2009)  Structure  17 : 1063 - 1074

PubMed: 19679086
DOI: 10.1016/j.str.2009.06.014

Reaction

Chain : A, B, C
UniProt : P19097 (FAS2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) 2.3.1.86 -
-
a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] 2.3.1.41 -
-
a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH 1.1.1.100 -
-
Chain : G, H, I
UniProt : P07149 (FAS1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) 2.3.1.86 -
-
acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA 2.3.1.38 -
-
holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP] 2.3.1.39 -
-
a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O 4.2.1.59 -
-
a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH 1.3.1.9 -
-
(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP] 3.1.2.14 -
-