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Ligands
Code Name Style Show Link
J3Z (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one
Non-standard Residues
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CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Code : 3HM1   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)
Release Data : 2010-06-02
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A,B ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1
mutation: Y537S
mol_id molecule chains synonym
2 Nuclear receptor coactivator 2 C,D NCoA-2, Transcriptional intermediary factor 2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR, ESR1, NR3A1
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: MCSG7
mol_id organism_scientific
2
synthetic: yes
Authors : Rajan, S.S., Kim, Y., Vanek, K., Liwanag, M., Joachimiak, A., Greene, G.L.
Keywords : estrogen receptor, LBD, GRIP peptide, estrone, Alternative splicing, DNA-binding, Glycoprotein, Lipid-binding, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc, Zinc-finger, Activator, HORMONE, NUCLEAR RECEPTOR
Exp. method : X-RAY DIFFRACTION ( 2.33 Å )
Citation :

Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one)

Rajan, S.S.,Kim, Y.,Vanek, K.  et al.
To be Published 

Chain : A, B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -
Chain : C, D
UniProt : Q9WUI9 (NCOA2_RAT)
Reaction : -