Brand  (β version)

PDB ID: 3HLV

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Ligands
Code Name Style Show Link
J2Z (9beta,13alpha,16beta)-3,16-dihydroxyestra-1,3,5(10)-trien-17-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HLV   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and 16-alpha-hydroxy-estrone ((8S,9R,13S,14R,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one
Release Data : 2010-06-02
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A,B ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1
fragment: UNP residues 298-550
mutation: Y537S
mol_id molecule chains synonym
2 Nuclear receptor coactivator 2 C,D NCoA-2, Transcriptional intermediary factor 2
fragment: UNP residues 686-698
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR, ESR1, NR3A1
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: MCSG7
mol_id organism_scientific
2
synthetic: yes
Authors : Rajan, S.S., Kim, Y., Vanek, K., Joachimiak, A., Greene, G.L.
Keywords : estrogen receptor, LBD, GRIP peptide, hydroxy-estrone, Alternative splicing, DNA-binding, Glycoprotein, Lipid-binding, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc, Zinc-finger, Activator, HORMONE, NUCLEAR RECEPTOR
Exp. method : X-RAY DIFFRACTION ( 3.000 Å )
Citation :

Crystal structure of human alphaER-LBD in complex with GRIP peptide and 16alpha-hydroxyestrone

Rajan, S.S.,Kim, Y.,Vanek, K.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -
Chain : C, D
UniProt : Q9WUI9 (NCOA2_RAT)
Reaction : -