Brand  (β version)

PDB ID: 3HIO

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Ligands
Code Name Style Show Link
C2X 9,9'-{(2r,3r,3ar,5s,7ar,9r,10r,10ar,12s,23r,25ar,27r,28r,28ar,30s,32ar,35ar,37s,39ar)-9-(6-amino-9h-purin-9-yl)-34-[(4-amino-5h-pyrrolo[3,2-D]pyrimidin-7-yl)methyl]-5,12,23,30,37-pentahydroxy-3,10,28-trimethoxy-5,12,23,30,37-pentaoxidotetracosahydro-2h,7h,25h-trifuro[3,2-f:3',2'-L:3'',2''-x]pyrrolo[3,4-R][1,3,5,9,11,15,17,21,23,27,29,2,4,10,16,22,28]undecaoxazapentaphosphacyclopentatriacontine-2,27-diyl}bis(2-amino-3,9-dihydro-6h-purin-6-one) PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3HIO   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase inhibitor
Title : Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue
Release Data : 2009-12-08
Compound :
mol_id molecule chains synonym
1 Ricin A Ricin A chain, rRNA N-glycosidase
ec: 3.2.2.22
Source :
mol_id organism_scientific organism_common expression_system
1 Ricinus communis  (taxid:3988) Castor bean Escherichia coli  (taxid:562)
expression_system_strain: C43
expression_system_vector_type: plasmid
expression_system_plasmid: pET23a
Authors : Ho, M., Sturm, M.B., Goldman, J.D., Almo, S.C., Schramm, V.L.
Keywords : RTA, transition state, ribosome inactivating proteins, RIPs, Disulfide bond, Glycoprotein, Hydrolase, Lectin, Nucleotide-binding, Plant defense, Protein synthesis inhibitor, Toxin, Hydrolase-Hydrolase inhibitor COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins.

Ho, M.C.,Sturm, M.B.,Almo, S.C.  et al.
(2009)  Proc.Natl.Acad.Sci.USA  106 : 20276 - 20281

PubMed: 19920175
DOI: 10.1073/pnas.0911606106

Reaction

Chain : A
UniProt : P02879 (RICI_RICCO)
Reaction: EC: Evidence:
Physiological Direction:
[Ricin A chain]
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. 		3.2.2.22 -
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