Het-PDB Navi2 (PDB: 3HHI)

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Ligands
Code	Name	Link
074	[propylamino-3-hydroxy-butan-1,4-dionyl]-isoleucyl-proline	PoSSuM
TRS	2-amino-2-hydroxymethyl-propane-1,3-diol	PoSSuM
GOL	Glycerol	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Download interaction data: 3HHI

Code :

3HHI PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of Cathepsin B from T. brucei in complex with CA074

Release Data :

2010-05-26

Compound :

mol_id	molecule	chains	synonym
1	Cathepsin B-like cysteine protease	A,B	Cysteine peptidase C (CPC)
	ec: 3.4.22.- fragment: UNP residues 23 to 340 mutation: N216D

Source :

mol_id	organism_scientific	expression_system
1	Trypanosoma brucei (taxid:5691)	Pichia pastoris (taxid:4922)
	strain: Trypanosoma brucei brucei gene: Tb927.6.560, tbCatB expression_system_strain: X33 expression_system_vector_type: Plasmid expression_system_plasmid: pPICZalpha-A

Authors :

Wu, P., Kerr, I.D., Brinen, L.S.

Keywords :

cysteine protease, occluding loop, Hydrolase, Protease, Thiol protease

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei

Kerr, I.D.,Wu, P.,Marion-Tsukamaki, R. et al.
(2010) Plos Negl Trop Dis 4 : e701 - e701

PDB ID: 3HHI