Brand  (β version)

PDB ID: 3HC6

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
088 3-[(5-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1h-indol-1-yl)methyl]benzoic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3HC6   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : FXR with SRC1 and GSK088
Release Data : 2009-07-21
Compound :
mol_id molecule chains synonym
1 Bile acid receptor A Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
fragment: Ligand Binding Domain
mol_id molecule chains
2 Nuclear receptor coactivator 1 B
fragment: LXXLL Motif
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BAR, FXR, HRR1, NR1H4, RIP14
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pRSETA
mol_id organism_scientific
2
synthetic: yes
Authors : Williams, S.P., Madauss, K.P.
Keywords : FXR, nuclear receptor, GW4064, alpha-helical sandwich, Activator, Alternative splicing, DNA-binding, Metal-binding, Nucleus, Receptor, Repressor, Transcription, Transcription regulation, Zinc, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 3.200 Å )
Citation :

FXR agonist activity of conformationally constrained analogs of GW 4064.

Akwabi-Ameyaw, A.,Bass, J.Y.,Caldwell, R.D.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 4733 - 4739

PubMed: 19586769
DOI: 10.1016/j.bmcl.2009.06.062

Reaction

Chain : A
UniProt : Q96RI1 (NR1H4_HUMAN)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-