Het-PDB Navi2 (PDB: 3HA6)

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Ligands
Code	Name		Style	Show	Link
2JZ	N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 3HA6

Code :

3HA6 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of aurora A in complex with TPX2 and compound 10

Release Data :

2009-08-04

Compound :

mol_id	molecule	chains	synonym
1	Serine/threonine-protein kinase 6	A	Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase
	ec: 2.7.11.1 fragment: UNP residues 125-391

mol_id	molecule	chains	synonym
2	Targeting protein for Xklp2	B	Restricted expression proliferation-associated protein 100, p100, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Protein fls353, Hepatocellular carcinoma-associated antigen 519
	fragment: UNP residues 1-43

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	ESCHERICHIA COLI (taxid:562)
	gene: AIK, ARK1, AURA, AURKA, BTAK, STK15, STK6 expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_plasmid: PDEST17 TEV AURORA A 125-391

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	ESCHERICHIA COLI (taxid:562)
	gene: C20orf1, C20orf2, DIL2, HCA519, TPX2 expression_system_strain: BL21 expression_system_vector_type: PLASMID expression_system_plasmid: PDEST17 TEV AURORA A 125-391

Authors :

Zhao, B., Clark, M.A.

Keywords :

AURORA A, SERINE/THREONINE-PROTEIN KINASE, COFACTOR, TPX2, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, CELL CYCLE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, NUCLEUS, Kinase

Exp. method :

X-RAY DIFFRACTION ( 2.36 Å )

Citation :

Design, synthesis and selection of DNA-encoded small-molecule libraries.

Clark, M.A.,Acharya, R.A.,Arico-Muendel, C.C. et al.
(2009) Nat.Chem.Biol. 5 : 647 - 654

PubMed: 19648931
DOI: 10.1038/nchembio.211

Chain :

UniProt :

O14965 (AURKA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-

Chain :	B
UniProt :	Q9ULW0 (TPX2_HUMAN)
Reaction :	-

PDB ID: 3HA6

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Structure summary

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