Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
2JZ N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine
Modified Residues
Code Name Link
TPO Phosphothreonine
Code : 3HA6
Header : TRANSFERASE
Title : Crystal structure of aurora A in complex with TPX2 and compound 10
Release Data : 2009-08-04
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase 6 A Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase
ec: 2.7.11.1
fragment: UNP residues 125-391
mol_id molecule chains synonym
2 Targeting protein for Xklp2 B Restricted expression proliferation-associated protein 100, p100, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Protein fls353, Hepatocellular carcinoma-associated antigen 519
fragment: UNP residues 1-43
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: AIK, ARK1, AURA, AURKA, BTAK, STK15, STK6
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PDEST17 TEV AURORA A 125-391
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: C20orf1, C20orf2, DIL2, HCA519, TPX2
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PDEST17 TEV AURORA A 125-391
Authors : Zhao, B., Clark, M.A.
Keywords : AURORA A, SERINE/THREONINE-PROTEIN KINASE, COFACTOR, TPX2, INHIBITOR, PHOSPHORYLATION, ATP-BINDING, CELL CYCLE, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, TRANSFERASE, NUCLEUS, Kinase
Exp. method : X-RAY DIFFRACTION ( 2.36 Å )
Citation :

Design, synthesis and selection of DNA-encoded small-molecule libraries.

Clark, M.A.,Acharya, R.A.,Arico-Muendel, C.C.  et al.
(2009)  Nat.Chem.Biol.  5 : 647 - 654

PubMed: 19648931
DOI: 10.1038/nchembio.211

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
Chain : B
UniProt : Q9ULW0 (TPX2_HUMAN)
Reaction : -