Brand  (β version)

PDB ID: 3H9O

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Ligands
Code Name Style Show Link
9BD 2-(1h-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[C][2,7]naphthyridin-4-amine PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 3H9O   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9
Release Data : 2009-08-25
Compound :
mol_id molecule chains synonym
1 3-phosphoinositide-dependent protein kinase 1 A hPDK1
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Olland, A.M.
Keywords : PDK-1, kinase, protein structure, X-ray crysatllography, Alternative splicing, ATP-binding, Cytoplasm, Membrane, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

Benzo[c][2,7]naphthyridines as inhibitors of PDK-1

Kim, K.H.,Wissner, A.,Floyd, M.B.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 5225 - 5228

PubMed: 19628388
DOI: 10.1016/j.bmcl.2009.07.007

Reaction

Chain : A
UniProt : O15530 (PDPK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:9368760
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:9368760
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