Brand  (β version)

PDB ID: 3H7W

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Ligands
Code Name Style Show Link
018 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3H7W   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017
Release Data : 2010-01-12
Compound :
mol_id molecule chains synonym
1 Endothelial PAS domain-containing protein 1 A EPAS-1, Member of PAS protein 2, Basic-helix-loop-helix-PAS protein MOP2, Hypoxia-inducible factor 2 alpha, HIF-2 alpha, HIF2 alpha, HIF-1 alpha-like factor, HLF
fragment: HIF2alpha C-terminal PAS domain (UNP residues 239 to 350)
mutation: R247E
mol_id molecule chains synonym
2 Aryl hydrocarbon receptor nuclear translocator B ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1 beta, HIF-1 beta
fragment: ARNT C-terminal PAS domain (UNP residues 356 to 470)
mutation: E362R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EPAS1, HIF2A, Hypoxia Inducible Factor 2 alpha, MOP2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: phis-GB1-HIF2aPAS-B
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ARNT, Aryl Hydrocarbon Receptor Nuclear Translocator, BHLHE2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: phis-GB1-ARNT-PAS-B
Authors : Key, J.M., Scheuermann, T.H., Anderson, P.C., Daggett, V., Gardner, K.H.
Keywords : PAS domain, heterodimer, protein ligand complex., Activator, Angiogenesis, Congenital erythrocytosis, Developmental protein, Differentiation, Disease mutation, DNA-binding, Hydroxylation, Nucleus, Phosphoprotein, Transcription, Transcription regulation, Ubl conjugation, Alternative splicing, Polymorphism
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B

Key, J.,Scheuermann, T.H.,Anderson, P.C.  et al.
(2009)  J.Am.Chem.Soc.  131 : 17647 - 17654

PubMed: 19950993
DOI: 10.1021/ja9073062

Reaction

Chain : A
UniProt : Q99814 (EPAS1_HUMAN)
Reaction : -
Chain : B
UniProt : P27540 (ARNT_HUMAN)
Reaction : -