Het-PDB Navi2 (PDB: 3H6T)

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Ligands
Code	Name	Link
GLU	Glutamic acid	PoSSuM
CYZ	Cyclothiazide	PoSSuM
ZN	Zinc ion	PoSSuM
GOL	Glycerol	PoSSuM
ACT	Acetate ion	PoSSuM
DMS	Dimethyl sulfoxide	PoSSuM

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Download interaction data: 3H6T

Code :

3H6T PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution

Release Data :

2009-07-28

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2	A,B,C	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
	fragment: iGluR2-flop ligand-binding core: UNP residues 413-796 mutation: N754S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Rat	Escherichia coli (taxid:562)
	gene: Gria2, Glur2 expression_system_strain: BL21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pET30b

Authors :

Hald, H., Gajhede, M., Kastrup, J.S.

Keywords :

AMPA receptor ligand-binding core, iGluR2 S1S2J-N754S, cyclothiazide, allosteric modulation, MEMBRANE PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.25 Å )

Citation :

Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

Hald, H.,Ahring, P.K.,Timmermann, D.B. et al.
(2009) J.Mol.Biol. 391 : 906 - 917

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.

Armstrong, N.,Gouaux, E.
(2000) Neuron 28 : 165 - 181

Mechanism of glutamate receptor desensitization.

Sun, Y.,Olson, R.,Horning, M. et al.
(2002) Nature 417 : 245 - 253

PDB ID: 3H6T