Het-PDB Navi2 (PDB: 3H5X)

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Ligands
Code	Name	Link
CSG	2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate)	PoSSuM
GOL	Glycerol	PoSSuM
MN	Manganese (II) ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3H5X

Code :

3H5X PDBj RCSB PDB PDBe

Header :

Transferase/RNA

Title :

Crystal Structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to Norovirus GII RNA polymerase

Release Data :

2009-05-19

Compound :

mol_id	molecule	chains
1	RNA dependent RNA polymerase	A
	ec: 2.7.7.48

mol_id	molecule	chains
2	5'-R(UPGPCPCPCPGPGPG)-3'	P
	other_details: Primer RNA

mol_id	molecule	chains
3	5'-R(PUPGPCPCPCPGPGPGP*C)-3'	T
	other_details: Template RNA

Source :

mol_id	organism_scientific	expression_system
1	Norwalk virus (taxid:11983)	Escherichia coli (taxid:562)
	strain: AST6139/01/SP gene: polymerase expression_system_strain: XL1-Blue expression_system_vector_type: Plasmid expression_system_plasmid: pGEX-2T

mol_id	organism_scientific
2
	synthetic: yes

mol_id	organism_scientific
3
	synthetic: yes

Authors :

Zamyatkin, D.F., Parra, F., Machin, A., Grochulski, P., Ng, K.K.S.

Keywords :

POLYMERASE-RNA COMPLEX, NON-NATURAL NUCLEOSIDE TRIPHOSPHATE ANALOG, CALICIVIRUS, Hydrolase, Nucleotide-binding, Nucleotidyltransferase, Protease, RNA replication, RNA-directed RNA polymerase, Thiol protease, Transferase, Transferase-RNA COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 1.77 Å )

Citation :

Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.

Zamyatkin, D.F.,Parra, F.,Machin, A. et al.
(2009) J.Mol.Biol. 390 : 10 - 16

PubMed: 19426741
DOI: 10.1016/j.jmb.2009.04.069

PDB ID: 3H5X

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