Brand  (β version)

PDB ID: 3H10

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Ligands
Code Name Style Show Link
97B 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5h-pyrimido[5,4-D][2]benzazepin-2-amine PoSSuM
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Structure summary

Code : 3H10   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aurora A inhibitor complex
Release Data : 2009-07-07
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase 6 A,B,D Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase
ec: 2.7.11.1
fragment: Kinase domain (UNP residues 124-391)
mutation: K124A, T287A, T288A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6
Authors : Wiesmann, C., Ultsch, M.H., Cochran, A.G.
Keywords : Protein:Inhibitor complex Aurora-A, Cell cycle, Serine/threonine, protein kinase, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.

Aliagas-Martin, I.,Burdick, D.,Corson, L.  et al.
(2009)  J.Med.Chem.  52 : 3300 - 3307

PubMed: 19402633
DOI: 10.1021/jm9000314

Reaction

Chain : A, B, D
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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