Het-PDB Navi2 (PDB: 3GWT)

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Ligands
Code	Name	Link
066	6-{[3-(dimethylcarbamoyl)phenyl]sulfonyl}-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide	PoSSuM
ZN	Zinc ion	PoSSuM
MG	Magnesium ion	PoSSuM
ARS	Arsenic	PoSSuM
GOL	Glycerol	PoSSuM

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Download interaction data: 3GWT

Code :

3GWT PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor

Release Data :

2010-04-07

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	A	DPDE4, PDE32
	ec: 3.1.4.17 fragment: Catalytic domain, residues 324-675 mutation: S654A, S659A, S661A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PDE4B, DPDE4 expression_system_vector_type: Baculovirus

Authors :

Somers, D.O., Neu, M.

Keywords :

PDE, PHOSPHODIESTERASE, cAMP, Hydrolase

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.

Woodrow, M.D.,Ballantine, S.P.,Barker, M.D. et al.
(2009) Bioorg.Med.Chem.Lett. 19 : 5261 - 5265

Chain :

UniProt :

Q07343 (PDE4B_HUMAN)

PDB ID: 3GWT