Brand  (β version)

PDB ID: 3GKI

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 3GKI   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : NPC1(NTD):cholesterol
Release Data : 2009-07-14
Compound :
mol_id molecule chains
1 Niemann-Pick C1 protein A
mutation: N70Q, N122Q, N185Q
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: NPC1
Authors : Kwon, H.J.
Keywords : cholesterol, cholesterol transfer, Disease mutation, Endosome, Glycoprotein, Lysosome, Membrane, Transmembrane, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.

Kwon, H.J.,Abi-Mosleh, L.,Wang, M.L.  et al.
(2009)  Cell(Cambridge,Mass.)  137 : 1213 - 1224

PubMed: 19563754
DOI: 10.1016/j.cell.2009.03.049

Reaction

Chain : A
UniProt : O15118 (NPC1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
cholesterol(in) = cholesterol(out) - PubMed:18772377
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