Brand  (β version)

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
ABA Alpha-aminobutyric acid
DAL D-alanine
JG3 1-[(2s,3s)-3-amino-2-hydroxy-4-phenylbutyl]-L-proline
NLE Norleucine
VME Methyl L-valinate
YCM S-(2-amino-2-oxoethyl)-L-cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
ACE Acetyl group
Code : 3GI0   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [L-ala51,D-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor
Release Data : 2011-08-10
Compound :
mol_id molecule chains
1 COVALENT DIMER [L-ALA51,D-ALA51'] HIV-1 PROTEASE A,B
ec: 3.4.23.16
mol_id molecule chains
2 JG-365 inhibitor C,D
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
synthetic: yes
other_details: total chemical protein synthesis
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
other_details: chemical peptide synthesis
Authors : Torbeev, V.Y., Kent, S.B.H.
Keywords : beta-barrel, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Correlations of protein dynamics with function in HIV-1 protease catalysis

Torbeev, V.Y.,Kent, S.B.H.
To be Published 

Chain : A, B
UniProt : P03369 (POL_HV1A2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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