Het-PDB Navi2 (PDB: 3G58)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
MG	Magnesium ion	PoSSuM
SO4	Sulfate ion	PoSSuM
988	8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline	PoSSuM
EDO	1,2-ethanediol	PoSSuM

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Download interaction data: 3G58

Code :

3G58 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of human phosphodiesterase 4d with d155988/pmnpq

Release Data :

2010-01-19

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	A,B,C,D	DPDE3, PDE43
	ec: 3.1.4.17 fragment: residues 380-753 mutation: S715A, S717A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PDE4D, DPDE3 expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PBACGUS

Authors :

Staker, B.L.

Keywords :

phosphodiesterase, PDE4D, Alternative splicing, cAMP, Cytoplasm, Cytoskeleton, Hydrolase, Membrane, Metal-binding, Phosphoprotein

Exp. method :

X-RAY DIFFRACTION ( 2.05 Å )

Citation :

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.

Burgin, A.B.,Magnusson, O.T.,Singh, J. et al.
(2010) Nat.Biotechnol. 28 : 63 - 70

Chain :

A, B, C, D

UniProt :

Q08499 (PDE4D_HUMAN)

PDB ID: 3G58