Brand  (β version)

PDB ID: 3G2J

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Ligands
Code Name Style Show Link
9GP N-(hydroxyacetyl)-beta-D-glucopyranosylamine PoSSuM
Non-standard Residues
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LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Structure summary

Code : 3G2J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of 1-(beta-D-glucopyranosyl)-4-substituted-1,2,3-triazoles in complex with glycogen phosphorylase
Release Data : 2010-02-16
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
Authors : Chrysina, E.D., Bokor, E., Alexacou, K.-M., Charavgi, M.-D., Oikonomakos, G.N., Zographos, S.E., Leonidas, D.D., Oikonomakos, N.G., Somsak, L.
Keywords : Glycogen phosphorylase, amide-1, 2, 3-triazole bioisosterism, Acetylation, Allosteric enzyme, Carbohydrate metabolism, Glycogen metabolism, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Pyridoxal phosphate, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.14 Å )
Citation :

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

Chrysina, E.D.,Bokor, E.,Alexacou, K.-M.  et al.
(2009)  Tetrahedron: Asymmetry  20 : 733 - 740

DOI: 10.1016/j.tetasy.2009.03.021

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

Watson, K.A.,Mitchell, E.P.,Johnson, L.N.  et al.
(1995)  Acta Crystallogr.,Sect.D  51 : 458 - 472

PubMed: 15299833
DOI: 10.1107/S090744499401348X

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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