Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
DAO Lauric acid
FTT 3-hydroxy-tetradecanoic acid
GCS D-glucosamine
GMH L-glycero-D-manno-heptopyranose
KDO 3-deoxy-D-manno-oct-2-ulosonic acid
MG Magnesium ion
MYR Myristic acid
NAG N-acetyl-D-glucosamine
PA1 2-amino-2-deoxy-alpha-D-glucopyranose
PO4 Phosphate ion
Code : 3FXI
Header : IMMUNE SYSTEM
Title : Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex
Release Data : 2009-03-03
Compound :
mol_id molecule chains synonym
1 Toll-like receptor 4 A,B TLR4, hToll
fragment: extracellular domain, residues 27-631
mol_id molecule chains synonym
2 Lymphocyte antigen 96 C,D MD-2, Protein MD-2, ESOP-1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: TLR4
expression_system_cell: HIGH FIVE CELLS
expression_system_vector_type: baculovirus
expression_system_plasmid: pAcGP67A
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: ESOP1, LY96, MD-2, MD2
expression_system_cell: HIGH FIVE CELLS
expression_system_vector_type: baculovirus
expression_system_plasmid: pAcGP67A
Authors : Park, B.S., Song, D.H., Kim, H.M., Lee, J.-O.
Keywords : Leucine Rich Repeat, Glycoprotein, Immune response, Inflammatory response, Innate immunity, Membrane, Receptor, Transmembrane, Secreted, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

Park, B.S.,Song, D.H.,Kim, H.M.  et al.
(2009)  Nature  458 : 1191 - 1195

PubMed: 19252480
DOI: 10.1038/nature07830

Chain : A, B
UniProt : O00206 (TLR4_HUMAN)
Reaction : -
Chain : C, D
UniProt : Q9Y6Y9 (LY96_HUMAN)
Reaction : -