PDB ID: 3FSF
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Structure summary
Code : | 3FSF PDBj RCSB PDB PDBe | ||||||||||||
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Header : | SIGNALING PROTEIN, TRANSFERASE | ||||||||||||
Title : | P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-D]pyrimidin-2-one | ||||||||||||
Release Data : | 2009-12-22 | ||||||||||||
Compound : |
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Source : |
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Authors : | Kuglstatter, A., Bertrand, J., Lovejoy, B. | ||||||||||||
Keywords : | P38; MAP KINASE; SERINE/THREONINE KINASE, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.10 Å ) | ||||||||||||
Citation : |
The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase
Soth, M.,Kuglstatter, A.,Goldstein, D.
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Reaction
Chain : | A | |||||||||||||
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UniProt : | Q16539 (MK14_HUMAN) | |||||||||||||
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