Brand  (β version)

PDB ID: 3FQQ

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
0BD 3-methyl-1-(2-methylpropyl)butyl 4-O-beta-L-gulopyranosyl-beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Structure summary

Code : 3FQQ   PDBj   RCSB PDB   PDBe
Header : METAL BINDING PROTEIN
Title : Crystal structure of a novel dimeric form of HCV NS5A domain I protein
Release Data : 2009-03-24
Compound :
mol_id molecule chains synonym
1 Non-structural protein 5A A,B NS5A
fragment: HCV NS5A
Source :
mol_id organism_scientific organism_common expression_system
1 Hepatitis C virus (isolate Con1)  (taxid:333284) HCV Escherichia coli  (taxid:562)
strain: HCV Genotype 1b; subtype Con1
gene: Nonstructural protein NS5A
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: PET24A
Authors : Love, R.A.
Keywords : HCV, NS5A, DOMAIN I, PHOSPHOPROTEIN, RNA-BINDING, METAL BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus

Love, R.A.,Brodsky, O.,Hickey, M.J.  et al.
(2009)  J.Virol.  83 : 4395 - 4403

PubMed: 19244328
DOI: 10.1128/JVI.02352-08

Reaction

Chain : A, B
UniProt : Q9WMX2 (POLG_HCVCO)
Reaction: EC: Evidence:
Physiological Direction:
[Serine protease/helicase NS3]
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 		3.4.21.98 UniProtKB:P27958
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[Serine protease/helicase NS3]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:27226535
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[Serine protease/helicase NS3]
ATP + H2O = ADP + H(+) + phosphate 		3.6.4.13 PubMed:27226535
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[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
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