Brand  (β version)

PDB ID: 3FQH

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Ligands
Code Name Style Show Link
057 N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1h-pyrrolo[2,3-B]pyridin-2-yl)-1h-indole-5-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3FQH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole
Release Data : 2009-03-10
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A,B Spleen tyrosine kinase
ec: 2.7.10.2
fragment: UNP residues 365-635, Protein kinase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: SYK
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Kuglstatter, A., Villasenor, A.G.
Keywords : SYK, SPLEEN TYPROSINE KINASE, KINASE INHIBITOR, 7-AZAINDOLE, Alternative splicing, ATP-binding, Host-virus interaction, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, SH2 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation
Exp. method : X-RAY DIFFRACTION ( 2.26 Å )
Citation :

Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.

Villasenor, A.G.,Kondru, R.,Ho, H.  et al.
(2009)  Chem.Biol.Drug Des.  73 : 466 - 470

PubMed: 19220318
DOI: 10.1111/j.1747-0285.2009.00785.x

Reaction

Chain : A, B
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
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