Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FKO 3-(2-chlorophenyl)-6-(2-fluorophenoxy)-2h-indazole
Code : 3FKO
Header : SIGNALING PROTEIN, TRANSFERASE
Title : P38 kinase crystal structure in complex with RO3668
Release Data : 2009-12-22
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.11.24
mutation: R57K
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2
Authors : Kuglstatter, A., Knapp, M.
Keywords : P38; MAP KINASE; SERINE/THREONINE KINASE, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity

Arora, N.,Williams, C.,Delano, W.  et al.
To be Published 

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.