Brand  (β version)

PDB ID: 3FJ6

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
CIH (2z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3FJ6   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2
Release Data : 2009-06-09
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase A DHOdehase, Dihydroorotate oxidase
ec: 1.3.3.1
fragment: residues 30-396
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Heikkila, T.
Keywords : Alpha-Beta Barrel TIM Barrel, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Polymorphism, Pyrimidine biosynthesis, Transit peptide
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

Davies, M.,Heikkila, T.,McConkey, G.A.  et al.
(2009)  J.Med.Chem.  52 : 2683 - 2693

PubMed: 19351152
DOI: 10.1021/jm800963t

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
-