Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ZN Zinc ion
Modified Residues
Code Name Link
00C 3-sulfo-D-alanine
NH2 Amino group
Code : 3FII
Header : HYDROLASE, TOXIN/PROTEIN TRANSPORT
Title : Crystal structure of Clostridium botulinum neurotoxin serotype F catalytic domain with an inhibitor (inh2)
Release Data : 2009-06-23
Compound :
mol_id molecule chains synonym
1 BOTULINUM NEUROTOXIN TYPE F A BoNT/F (Neurotoxin type F)
ec: 3.4.24.69
fragment: residues 1-419, catalytic domain
mol_id molecule chains synonym
2 fragment of Vesicle-associated membrane protein 2 B VAMP-2, Synaptobrevin-2
fragment: residues 27-58
mutation: Q58DCY
Source :
mol_id organism_scientific expression_system
1 Clostridium botulinum  (taxid:1491) Escherichia coli  (taxid:562)
gene: bonT/F
expression_system_strain: BL21(DE3)RIPL
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28b
mol_id organism_scientific
2
synthetic: yes
other_details: Sequence occurs in Homo sapiens
Authors : Agarwal, R., Swaminathan, S.
Keywords : Clostridium botulinum, BoNT F, VAMP, inhibitor, complex structure, Acetylation, Cell junction, HYDROLASE, TOXIN-PROTEIN TRANSPORT COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.

Agarwal, R.,Schmidt, J.J.,Stafford, R.G.  et al.
(2009)  Nat.Struct.Mol.Biol.  16 : 789 - 794

PubMed: 19543288
DOI: 10.1038/nsmb.1626

Chain : A
UniProt : Q57236 (No found in current UniProtKB/SwissProt)
Reaction : -
Chain : B
UniProt : P63027 (VAMP2_HUMAN)
Reaction : -