Brand  (β version)

PDB ID: 3FGO

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
MF4 Tetrafluoromagnesate(2-) PoSSuM
K Potassium ion PoSSuM
CZA (6ar,11as,11br)-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11h-pyrrolo[1',2':2,3]isoindolo[4,5,6-Cd]indol-11-one PoSSuM
MN Manganese (II) ion PoSSuM
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3FGO   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the E2 magnesium fluoride complex of the (SR) Ca2+-ATPase with bound CPA and AMPPCP
Release Data : 2009-04-07
Compound :
mol_id molecule chains synonym
1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 A,B SERCA1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, SR Ca(2+)-ATPase 1, Endoplasmic reticulum class 1/2 Ca(2+) ATPase
ec: 3.6.3.8
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
Authors : Laursen, M., Bublitz, M., Moncoq, K., Olesen, C., Moller, J.V., Young, H.S., Nissen, P., Morth, J.P.
Keywords : Calcium pump, SERCA, nonhydrolyzable ATP analog, P-Type-ATPase, phosphorylation, cyclopiazonic acid, CPA, Alternative splicing, ATP-binding, Calcium, Calcium transport, Endoplasmic reticulum, Hydrolase, Ion transport, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Sarcoplasmic reticulum, Transmembrane, Transport
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase.

Laursen, M.,Bublitz, M.,Moncoq, K.  et al.
(2009)  J.Biol.Chem. 

PubMed: 19289472
DOI: 10.1074/jbc.C900031200

Reaction

Chain : A, B
UniProt : P04191 (AT2A1_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate 7.2.2.10 PubMed:10914677, PubMed:11438520, PubMed:15189864, PubMed:18075584, PubMed:23996003, PubMed:29081402, PubMed:8117720
left-to-right PubMed:10914677