Brand  (β version)

PDB ID: 3FFG

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Ligands
Code Name Style Show Link
FFG (R)-6-(2'-((3-hydroxypyrrolidin-1-yl)methyl)biphenyl-4-yl)-1-(3-(5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1h-pyrazolo[3,4-C]pyridin-7(4h)-one PoSSuM
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Glycosylation
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Structure summary

Code : 3FFG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Factor XA in complex with the inhibitor (R)-6-(2'-((3- HYDROXYPYRROLIDIN-1-YL)METHYL)BIPHENYL-4-YL)-1-(3-(5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN- 7(4H)-ONE
Release Data : 2009-12-08
Compound :
mol_id molecule chains synonym
1 Coagulation factor X, heavy chain A factor Xa heavy chain, Stuart factor, Stuart-Prower factor, Factor X heavy chain
ec: 3.4.21.6
fragment: sequence database residues 235-468
mol_id molecule chains synonym
2 Coagulation factor X, light chain L factor X light chain, Stuart factor, Stuart-Prower factor
ec: 3.4.21.6
fragment: sequence database residues 127-178
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
other_details: Proteolytic cleavage product
Authors : Alexander, R.A.
Keywords : GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, Blood coagulation, Calcium, Cleavage on pair of basic residues, Protease, Secreted
Exp. method : X-RAY DIFFRACTION ( 1.540 Å )
Citation :

Phenyltriazolinones as potent factor Xa inhibitors.

Quan, M.L.,Pinto, D.J.,Rossi, K.A.  et al.
(2010)  Bioorg.Med.Chem.Lett.  20 : 1373 - 1377

PubMed: 20100660
DOI: 10.1016/j.bmcl.2010.01.011

Reaction

Chain : L
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
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