Brand  (β version)

PDB ID: 3FEI

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Ligands
Code Name Style Show Link
CTM (2s)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3FEI   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Design and biological evaluation of novel, balanced dual PPARa/G agonists
Release Data : 2009-10-20
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor alpha A PPAR-alpha, Nuclear receptor subfamily 1 group C member 1
fragment: PPARalpha ligand binding domain
mol_id molecule chains synonym
2 Peptide motif 5 of Nuclear receptor coactivator 1 Z SRC-1 Coactivator protein motif 5
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPARA, NR1C1, PPAR
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
mol_id organism_scientific
2
synthetic: yes
other_details: Chemically synthesis
Authors : Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M., Schlatter, D.
Keywords : NUCLEAR RECEPTOR, TRANSCRIPTION FACTOR, DIABETES, Activator, DNA-binding, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists

Grether, U.,Benardeau, A.,Benz, J.  et al.
(2009)  Chemmedchem  4 : 951 - 956

PubMed: 19326383
DOI: 10.1002/cmdc.200800425

Reaction

Chain : A
UniProt : Q07869 (PPARA_HUMAN)
Reaction : -
Chain : Z
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
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