Het-PDB Navi2 (PDB: 3FCK)

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Ligands
Code	Name		Style	Show	Link
FCK	3-({[3-({[(1e)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3FCK

Code :

3FCK PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Complex of UNG2 and a fragment-based design inhibitor

Release Data :

2009-04-28

Compound :

mol_id	molecule	chains	synonym
1	Uracil-DNA glycosylase	B	UDG
	ec: 3.2.2.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	ESCHERICHIA COLI (taxid:562)
	gene: UNG, DGU, UNG1, UNG15

Authors :

Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.

Keywords :

DNA REPAIR, URACIL, URACIL DNA GLYCOSYLASE, Alternative splicing, Disease mutation, DNA damage, Glycosidase, Host-virus interaction, Hydrolase, Mitochondrion, Nucleus, Phosphoprotein, Transit peptide

Exp. method :

X-RAY DIFFRACTION ( 1.640 Å )

Citation :

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

Chung, S.,Parker, J.B.,Bianchet, M. et al.
(2009) Nat.Chem.Biol. 5 : 407 - 413

PubMed: 19396178
DOI: 10.1038/nchembio.163

Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development

Jiang, T.L.,Krosky, D.J.,Seiple, L. et al.
(2005) J.Am.Chem.Soc. 127 : 17412

Mimicking damaged DNA with a small molecule inhibitor of human UNG2.

Krosky, D.J.,Bianchet, M.A.,Seiple, L. et al.
(2006) Nucleic Acids Res. 34 : 5872

Chain :	B
UniProt :	P13051
Reaction :	-

PDB ID: 3FCK

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