PDB ID: 3FCK
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Structure summary
Code : | 3FCK PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Complex of UNG2 and a fragment-based design inhibitor | ||||||||||||
Release Data : | 2009-04-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T. | ||||||||||||
Keywords : | DNA REPAIR, URACIL, URACIL DNA GLYCOSYLASE, Alternative splicing, Disease mutation, DNA damage, Glycosidase, Host-virus interaction, Hydrolase, Mitochondrion, Nucleus, Phosphoprotein, Transit peptide | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.640 Å ) | ||||||||||||
Citation : |
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
Chung, S.,Parker, J.B.,Bianchet, M.
et al.
PubMed: 19396178 Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development
Jiang, T.L.,Krosky, D.J.,Seiple, L.
et al.
Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Krosky, D.J.,Bianchet, M.A.,Seiple, L.
et al.
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Reaction
Chain : | B | ||||||||
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UniProt : | P13051 (UNG_HUMAN) | ||||||||
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