Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
FCK 3-({[3-({[(1e)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid
Code : 3FCK
Header : HYDROLASE
Title : Complex of UNG2 and a fragment-based design inhibitor
Release Data : 2009-04-28
Compound :
mol_id molecule chains synonym
1 Uracil-DNA glycosylase B UDG
ec: 3.2.2.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human ESCHERICHIA COLI  (taxid:562)
gene: UNG, DGU, UNG1, UNG15
Authors : Bianchet, M.A., Chung, S., Parker, J.B., Amzel, L.M., Stivers, J.T.
Keywords : DNA REPAIR, URACIL, URACIL DNA GLYCOSYLASE, Alternative splicing, Disease mutation, DNA damage, Glycosidase, Host-virus interaction, Hydrolase, Mitochondrion, Nucleus, Phosphoprotein, Transit peptide
Exp. method : X-RAY DIFFRACTION ( 1.640 Å )
Citation :

Impact of linker strain and flexibility in the design of a fragment-based inhibitor

Chung, S.,Parker, J.B.,Bianchet, M.  et al.
(2009)  Nat.Chem.Biol.  5 : 407 - 413

PubMed: 19396178
DOI: 10.1038/nchembio.163

Uracil-directed ligand tethering: an efficient strategy for uracil DNA glycosylase (UNG) inhibitor development

Jiang, T.L.,Krosky, D.J.,Seiple, L.  et al.
(2005)  J.Am.Chem.Soc.  127 : 17412

Mimicking damaged DNA with a small molecule inhibitor of human UNG2.

Krosky, D.J.,Bianchet, M.A.,Seiple, L.  et al.
(2006)  Nucleic Acids Res.  34 : 5872

Chain : B
UniProt : P13051 (UNG_HUMAN)
Reaction : Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.