Brand  (β version)

PDB ID: 3F7D

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Ligands
Code Name Style Show Link
P42 (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate PoSSuM
Non-standard Residues
Code Name Show
CAF S-dimethylarsinoyl-cysteine
Glycosylation
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Modification
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Structure summary

Code : 3F7D   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : SF-1 LBD bound by phosphatidylcholine
Release Data : 2008-12-09
Compound :
mol_id molecule chains synonym
1 nuclear receptor SF-1 A Steroidogenic factor-1, Nuclear receptor subfamily 5, group A, member 1
fragment: UNP residues 219-462
mutation: C302S, C408S, C413S, C423S, C267(CAF)
mol_id molecule chains synonym
2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha B PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PGC-1-alpha
fragment: UNP residues 137-150
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Nr5a1, Ftzf1, RP23-354G20.5-001
mol_id organism_scientific organism_common
2 Mus musculus  (taxid:10090) Mouse
synthetic: yes
Authors : Sablin, E.P., Fletterick, R.J.
Keywords : nuclear receptor, coactivator peptide, ligand, phospholipid, phosphatidylcholine, transcriptional regulation, DNA-binding, Metal-binding, Nucleus, Receptor, Transcription, Transcription regulation, Zinc-finger, Activator, RNA-binding
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

Sablin, E.P.,Blind, R.D.,Krylova, I.N.  et al.
(2009)  Mol.Endocrinol.  23 : 25 - 34

PubMed: 18988706
DOI: 10.1210/me.2007-0508

Reaction

Chain : A
UniProt : Q812G5 (STF1_MOUSE)
Reaction : -
Chain : B
UniProt : O70343 (PRGC1_MOUSE)
Reaction : -