Het-PDB Navi2 (PDB: 3F2A)

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Ligands
Code	Name		Style	Show	Link
985	(2e)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
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Download interaction data: 3F2A

Code :

3F2A PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human Pim-1 in complex with DAPPA

Release Data :

2009-03-10

Compound :

mol_id	molecule	chains	synonym
1	Proto-oncogene serine/threonine-protein kinase Pim-1	A	Pim1 protein kinase
	ec: 2.7.11.1 fragment: UNP residues 105-404

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda
	gene: PIM1 expression_system_common: Fall armyworm expression_system_strain: SF9

Authors :

Qian, K.

Keywords :

potein kinase fold, Alternative initiation, ATP-binding, Cell membrane, Cytoplasm, Kinase, Manganese, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Serine/threonine-protein kinase, Transferase

Exp. method :

X-RAY DIFFRACTION ( 1.9 Å )

Citation :

Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.

Qian, K.,Wang, L.,Cywin, C.L. et al.
(2009) J.Med.Chem. 52 : 1814 - 1827

PubMed: 19256503
DOI: 10.1021/jm801242y

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862
	-	PubMed:15525646, PubMed:15657054, PubMed:15808862

PDB ID: 3F2A

Hetero Atom Contents

Structure summary

Reaction