Het-PDB Navi2 (PDB: 3ELA)

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Ligands
Code	Name	Link
0Z6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide	PoSSuM
CA	Calcium ion	PoSSuM
FUC	Alpha-L-fucopyranose	PoSSuM
GLC	Alpha-D-glucopyranose	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3ELA

Code :

3ELA PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor

Release Data :

2008-11-04

Compound :

mol_id	molecule	chains
1	Coagulation factor VIIA light chain	L
	ec: 3.4.21.21 fragment: UNP residues 61-212

mol_id	molecule	chains
2	Coagulation factor VIIA heavy chain	H
	ec: 3.4.21.21 fragment: UNP residues 213-466 mutation: V158D,E296V,M298Q

mol_id	molecule	chains	synonym
3	Tissue factor	T	TF, Coagulation factor III, Thromboplastin
	fragment: UNP residues 33-241

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: F7 expression_system_common: Chinese hamster expression_system_cell: CHO-K1 expression_system_vector_type: PLASMID expression_system_plasmid: PEE-ACEDELTA36NJ

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: F7 expression_system_common: Chinese hamster expression_system_cell: CHO-K1 expression_system_vector_type: PLASMID expression_system_plasmid: PEE-ACEDELTA36NJ

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: F3 expression_system_vector_type: PLASMID expression_system_plasmid: pET_TF1-209

Authors :

Bjelke, J.R., Fodje, M., Svensson, L.A.

Keywords :

Serine protease, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity

Bjelke, J.R.,Olsen, O.H.,Fodje, M. et al.
(2008) J.Biol.Chem. 283 : 25863 - 25870

PubMed: 18640965
DOI: 10.1074/jbc.M800841200

Chain :

UniProt :

P08709 (FA7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.21	-
	-	-

Chain :	T
UniProt :	P13726 (TF_HUMAN)
Reaction :	-

PDB ID: 3ELA

Hetero Atom Contents

Structure summary

Reaction