Het-PDB Navi2 (PDB: 3ECR)

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Ligands
Code	Name		Style	Show	Link
DPM	3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1h-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid				PoSSuM

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Download interaction data: 3ECR

Code :

3ECR PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Structure of human porphobilinogen deaminase

Release Data :

2008-09-30

Compound :

mol_id	molecule	chains	synonym
1	Porphobilinogen deaminase	A,B	PBG-D, Pre-uroporphyrinogen synthase, Hydroxymethylbilane synthase, HMBS
	ec: 2.5.1.61

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HMBS, PBGD, UPS expression_system_strain: BL21DE3 expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Song, G., Li, Y., Cheng, C., Zhao, Y., Gao, A., Zhang, R., Joachimiak, A., Shaw, N., Liu, Z.J.

Keywords :

human porphobilinogen deaminase, heme biosynthesis, porphobilinogen hinge, Alternative splicing, Cytoplasm, Disease mutation, Porphyrin biosynthesis, Transferase

Exp. method :

X-RAY DIFFRACTION ( 2.182 Å )

Citation :

Structural insight into acute intermittent porphyria.

Song, G.,Li, Y.,Cheng, C. et al.
(2009) Faseb J. 23 : 396 - 404

PubMed: 18936296
DOI: 10.1096/fj.08-115469

Chain :

A, B

UniProt :

P08397 (HEM3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)	2.5.1.61	PubMed:18004775, PubMed:18936296, PubMed:19138865, PubMed:23815679
H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)	left-to-right	PubMed:19138865

PDB ID: 3ECR

Hetero Atom Contents

Structure summary

Reaction