Brand  (β version)

PDB ID: 3ECG

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Ligands
Code Name Style Show Link
065 (3r,3as,6ar)-hexahydrofuro[2,3-B]furan-3-yl(2s,3r)-3-hydroxy-4-(N-isobutylbenzo[D][1,3]dioxole-5-sulfonamido)-1-phenylbutan-2-ylcarbamate PoSSuM
CL Chloride ion PoSSuM
IMD Imidazole PoSSuM
NA Sodium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3ECG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : High Resolution HIV-2 Protease Structure in Complex with Antiviral Inhibitor GRL-98065
Release Data : 2008-09-16
Compound :
mol_id molecule chains
1 Protease A,B
ec: 3.4.23.47
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus type 2 (ISOLATE ROD)  (taxid:11720) Escherichia coli  (taxid:562)
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET11a
Authors : Kovalevsky, A.Y., Weber, I.T.
Keywords : HIV-2, aspartic protease, inhibitor, protease-inhibitor complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.18 Å )
Citation :

Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease

Kovalevsky, A.Y.,Louis, J.M.,Aniana, A.  et al.
(2008)  J.Mol.Biol.  384 : 178 - 192

PubMed: 18834890
DOI: 10.1016/j.jmb.2008.09.031

Reaction

Chain : A, B
UniProt : P04584 (POL_HV2RO)
Reaction: EC: Evidence:
Physiological Direction:
Endopeptidase for which the P1 residue is preferably hydrophobic. 3.4.23.47 PROSITE- ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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