Brand  (β version)

PDB ID: 3EBP

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CPB 2-(2-chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4h-benzopyran-4-one PoSSuM
Non-standard Residues
Code Name Show
LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3EBP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Glycogen Phosphorylase B/flavopiridol complex
Release Data : 2009-09-01
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Glycogen Phosphorylase b, Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) European rabbit,Japanese white rabbit,domestic rabbit,rabbits
tissue: Muscle
Authors : Oikonomakos, N.G., Zographos, S.E., Leonidas, D.D., Hayes, J.M., Tiraidis, C., Alexacou, K.-M.
Keywords : glycogen phosphorylase, rational inhibitor design, glycogenolysis, diabetes type 2, Allosteric enzyme, Carbohydrate metabolism, Glycogen metabolism, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Pyridoxal phosphate, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol

Tsitsanou, K.E.,Hayes, J.M.,Keramioti, M.  et al.
(2013)  Food Chem.Toxicol.  61 : 14 - 27

PubMed: 23279842
DOI: 10.1016/j.fct.2012.12.030

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
left-to-right