Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
B2 (2r)-5-fluoro-2-(2-thienyl)-1,2-dihydroquinazolin-4-amine
H4B 5,6,7,8-tetrahydrobiopterin
HEM Protoporphyrin ix containing Fe
SO4 Sulfate ion
ZN Zinc ion
Code : 3E7I
Title : Structure of murine inos oxygenase domain with inhibitor AR-C94864
Release Data : 2008-10-07
Compound :
mol_id molecule chains synonym
1 Nitric oxide synthase, inducible A,B NOS TYPE II, INDUCIBLE NOS, INOS, MACROPHAGE NOS, MAC-NOS
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Nos2, Inosl
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PCWORI
Authors : Garcin, E.D., Arvai, A.S., Rosenfeld, R.J., Kroeger, M.D., Crane, B.R., Andersson, G., Andrews, G., Hamley, P.J., Mallinder, P.R., Nicholls, D.J., St-Gallay, S.A., Tinker, A.C., Gensmantel, N.P., Mete, A., Cheshire, D.R., Connolly, S., Stuehr, D.J., Aberg, A., Wallace, A.V., Tainer, J.A., Getzoff, E.D.
Keywords : NITRIC OXIDE SYNTHASE, NOS, HEME, TETRAHYDROBIOPTERIN, OXIDOREDUCTASE Calmodulin-binding, FAD, FMN, Iron, Metal-binding, NADP, Oxidoreductase, Polymorphism, Zinc
Exp. method : X-RAY DIFFRACTION ( 2.900 Å )
Citation :

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.  et al.
(2008)  Nat.Chem.Biol.  4 : 700 - 707

PubMed: 18849972
DOI: 10.1038/nchembio.115

Chain : A, B
UniProt : P29477 (NOS2_MOUSE)
Reaction : 2 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.