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Ligands
Code Name Style Show Link
CCK [1-(6-{6-[(1-methylethyl)amino]-1h-indazol-1-yl}pyrazin-2-yl)-1h-pyrrol-3-yl]acetic acid
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Code : 3E3B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of catalytic subunit of human protein kinase CK2alpha prime with a potent indazole-derivative inhibitor
Release Data : 2009-03-03
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha' X casein kinase CK2 alpha prime, CK II
ec: 2.7.11.1
fragment: residues in database 1-334
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A2, CK2A2
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX-6P-1
Authors : Kinoshita, T., Nakaniwa, T., Tada, T.
Keywords : Casein Kinase 2, CK2alpha prime, CK2alpha inhibitor, selective kinase inhibitor, ATP-binding, Kinase, Nucleotide-binding, Polymorphism, Serine/threonine-protein kinase, Transferase, Wnt signaling pathway
Exp. method : X-RAY DIFFRACTION ( 3.2 Å )
Citation :

Structure of human protein kinase CK2alpha2 with a potent indazole-derivative inhibitor

Nakaniwa, T.,Kinoshita, T.,Sekiguchi, Y.  et al.
(2009)  Acta Crystallogr.,Sect.F  65 : 75 - 79

PubMed: 19193990
DOI: 10.1107/S1744309108043194

Chain : X
UniProt : P19784 (CSK22_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:11239457, PubMed:20545769, PubMed:21482717, PubMed:30898438
left-to-right PubMed:11239457, PubMed:20545769, PubMed:21482717, PubMed:30898438, PubMed:35597237
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:22325354
left-to-right