Brand  (β version)

PDB ID: 3DU7

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Ligands
Code Name Style Show Link
CN2 2-mercapto-N-[1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]acetamide PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
HOS Phomopsin a PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3DU7   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE
Title : Tubulin-colchicine-phomopsin A: Stathmin-like domain complex
Release Data : 2008-10-21
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1C chain A,C tubulin alpha chain
mol_id molecule chains synonym
2 Tubulin beta-2B chain B,D tubulin beta chain
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3, RB3
fragment: RB3 stathmin-like domain 4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
organ: brain
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
organ: brain
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Stmn4
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-8C
Authors : Cormier, A., Marchand, M., Ravelli, R.B., Knossow, M., Gigant, B.
Keywords : alpha-tubulin, beta-tubulin, colchicine, gtpase, microtubule, phomopsin A, stathmin, tubulin, GTP-binding, Nucleotide-binding, Phosphoprotein, CELL CYCLE
Exp. method : X-RAY DIFFRACTION ( 4.10 Å )
Citation :

Structural insight into the inhibition of tubulin by vinca domain peptide ligands

Cormier, A.,Marchand, M.,Ravelli, R.B.  et al.
(2008)  Embo Rep.  9 : 1101 - 1106

PubMed: 18787557
DOI: 10.1038/embor.2008.171

Reaction

Chain : A, C
UniProt : Q3ZCJ7 (TBA1C_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate - UniProtKB:P68363
left-to-right
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -