Brand  (β version)

PDB ID: 3DSL

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FLE Furoyl-leucine PoSSuM
TRP Tryptophan PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Structure summary

Code : 3DSL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The Three-dimensional Structure of Bothropasin, the Main Hemorrhagic Factor from Bothrops jararaca venom.
Release Data : 2008-10-21
Compound :
mol_id molecule chains synonym
1 Zinc metalloproteinase-disintegrin bothropasin A,B Disintegrin bothropasin
ec: 3.4.24.49
Source :
mol_id organism_scientific organism_common
1 Bothrops jararaca  (taxid:8724) Jararaca
Authors : Muniz, J.R.C., Ambrosio, A., Selistre-de-Araujo, H.S., Oliva, G., Garratt, R.C., Souza, D.H.F.
Keywords : Snake venom, metalloprotease, disintegrin, Blood coagulation, Cell adhesion, Glycoprotein, Hydrolase, Metal-binding, Protease, Secreted, Toxin, Zymogen
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups.

Muniz, J.R.,Ambrosio, A.L.,Selistre-de-Araujo, H.S.  et al.
(2008)  Toxicon  52 : 807 - 816

PubMed: 18831982
DOI: 10.1016/j.toxicon.2008.08.021

Reaction

Chain : A, B
UniProt : O93523 (VM3BP_BOTJA)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of 5-His-|-Leu-6, 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 in insulin B chain. 3.4.24.49 PubMed:6819660
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