Brand  (β version)

PDB ID: 3DR1

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Ligands
Code Name Style Show Link
C5D (1r,3r)-5-[(2e)-3-{(1s,3r)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol PoSSuM
MG Magnesium ion PoSSuM
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Glycosylation
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Structure summary

Code : 3DR1   PDBj   RCSB PDB   PDBe
Header : GENE REGULATION/TRANSFERASE
Title : Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor
Release Data : 2009-06-16
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A A VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A
fragment: Ligand binding domain
mol_id molecule chains synonym
2 SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1 B NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52
ec: 2.3.1.48
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebra fish Escherichia coli  (taxid:562)
gene: vdra, nr1i1a, vdr
expression_system_strain: Bl21de3
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28b
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Sato, Y., Rochel, N., Moras, D.
Keywords : GENE REGULATION, DNA-binding, Metal-binding, Nucleus, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Activator, Acyltransferase, Alternative splicing, Chromosomal rearrangement, Phosphoprotein, Polymorphism, Proto-oncogene, Transferase, Ubl conjugation, GENE REGULATION-TRANSFERASE COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.

Eelen, G.,Valle, N.,Sato, Y.  et al.
(2008)  Chem.Biol.  15 : 1029 - 1034

PubMed: 18940664
DOI: 10.1016/j.chembiol.2008.08.008

Reaction

Chain : A
UniProt : Q9PTN2 (VDRA_DANRE)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-