Brand  (β version)

PDB ID: 3DDW

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Ligands
Code Name Style Show Link
055 (2s)-{[(3-{[(2-chloro-6-methylphenyl)carbamoyl]amino}naphthalen-2-yl)carbonyl]amino}(phenyl)ethanoic acid PoSSuM
CFF Caffeine PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
NBG N-acetyl-beta-D-glucopyranosylamine PoSSuM
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 3DDW   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK055
Release Data : 2009-01-27
Compound :
mol_id molecule chains
1 Glycogen phosphorylase, liver form A,B
ec: 2.4.1.1
Source :
mol_id organism_scientific expression_system
1 Homo sapiens  (taxid:9606) Escherichia coli  (taxid:562)
tissue: Liver isoform
gene: PYGL
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: T7 promoter
Authors : Nolte, R.T.
Keywords : Glycogen Phosphorylase, GP, Diabetes, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Pyridoxal phosphate, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.

Thomson, S.A.,Banker, P.,Bickett, D.M.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 1177 - 1182

PubMed: 19138846
DOI: 10.1016/j.bmcl.2008.12.085

Reaction

Chain : A, B
UniProt : P06737 (PYGL_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 PubMed:22225877
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