Brand  (β version)

PDB ID: 3DB6

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Ligands
Code Name Style Show Link
FRS 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2z)-5-(2-{[6-(1h-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3h)-ylidene]urea PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3DB6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
Release Data : 2008-08-19
Compound :
mol_id molecule chains
1 Polo-like kinase 1 A
ec: 2.7.11.21
fragment: PLK1 kinase domain
mutation: T196D
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebra fish Escherichia coli
gene: plk1
expression_system_strain: BL21(DE3) Star Codon+
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX6P-1
Authors : Elling, R.A., Fucini, R.V., Zhu, J., Barr, K.J., Romanowski, M.J.
Keywords : Polo-like kinase 1, Plk1, catalytic domain, small-molecule inhibitor, Kinase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.85 Å )
Citation :

Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.

Elling, R.A.,Fucini, R.V.,Hanan, E.J.  et al.
(2008)  Acta Crystallogr.,Sect.F  64 : 686 - 691

PubMed: 18678933
DOI: 10.1107/S1744309108019623

Reaction

Chain : A
UniProt : Q4KMI8 (Q4KMI8_DANRE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.21 ARBA:ARBA00000540
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.21 ARBA:ARBA00000856, RuleBase:RU361162
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