Het-PDB Navi2 (PDB: 3D81)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM

Non-standard Residues
Code	Name	Show
FZN	(2s)-2-amino-6-{[(1z)-1-{[(2r,3r,4s,5r)-5-({[(R)-{[(R)-{[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxytetrahydrofuran-2-yl]sulfanyl}ethylidene]amino}hexanoic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3D81

Code :

3D81 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Sir2-S-alkylamidate complex crystal structure

Release Data :

2008-09-30

Compound :

mol_id	molecule	chains	synonym
1	NAD-dependent deacetylase	A	Regulatory protein SIR2 homolog
	ec: 3.5.1.-

mol_id	molecule	chains
2	S-alkylamidate intermediate	C

Source :

mol_id	organism_scientific	expression_system
1	Thermotoga maritima (taxid:2336)	ESCHERICHIA COLI
	gene: npdA, TM_0490 expression_system_strain: BL-21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET11A

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Hawse, W.F., Hoff, K.G., Fatkins, D., Daines, A., Zubkova, O.V., Schramm, V.L., Zheng, W., Wolberger, C.

Keywords :

Rossmann fold, NAD dependent deacetylase, Cytoplasm, Hydrolase, Metal-binding, NAD, Zinc

Exp. method :

X-RAY DIFFRACTION ( 2.500 Å )

Citation :

Structural insights into intermediate steps in the Sir2 deacetylation reaction.

Hawse, W.F.,Hoff, K.G.,Fatkins, D.G. et al.
(2008) Structure 16 : 1368 - 1377

Chain :

UniProt :

Q9WYW0 (NPD_THEMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide	2.3.1.286	HAMAP-Rule:MF_01968, PubMed:15780941, PubMed:16905097
	-	HAMAP-Rule:MF_01968, PubMed:15780941, PubMed:16905097

PDB ID: 3D81