Het-PDB Navi2 (PDB: 3D6Z)

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Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM
RHQ	Rhodamine 6g				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3D6Z

Code :

3D6Z PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION REGULATOR/DNA

Title :

Crystal structure of R275E mutant of BMRR bound to DNA and rhodamine

Release Data :

2008-08-26

Compound :

mol_id	molecule	chains
1	BMR promoter DNA	B

mol_id	molecule	chains
2	Multidrug-efflux transporter 1 regulator	A
	fragment: residues 1-278 mutation: R275E, A277L, E278D

Source :

mol_id	organism_scientific
1	Synthetic construct (taxid:32630)
	synthetic: yes

mol_id	organism_scientific	expression_system
2	Bacillus subtilis (taxid:1423)	Escherichia coli (taxid:562)
	gene: bmrR, bmr1R expression_system_strain: TOP10 expression_system_vector_type: PLASMID expression_system_plasmid: PBAD

Authors :

Newberry, K.J., Brennan, R.G.

Keywords :

MULTIDRUG RESISTANCE, TRANSCRIPTION REGULATION, PROTEIN-DNA COMPLEX, Activator, DNA-binding, TRANSCRIPTION REGULATOR-DNA COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.60 Å )

Citation :

Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion

Newberry, K.J.,Huffman, J.L.,Miller, M.C. et al.
(2008) J.Biol.Chem. 283 : 26795 - 26804

PDB ID: 3D6Z