Brand  (β version)

PDB ID: 3D4S

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
TIM (2s)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3D4S   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Cholesterol bound form of human beta2 adrenergic receptor.
Release Data : 2008-06-17
Compound :
mol_id molecule chains synonym
1 Beta-2 adrenergic receptor/T4-lysozyme chimera A Beta-2 adrenoceptor, Beta-2 adrenoreceptor / Lysis protein, Muramidase, Endolysin
mutation: E122W, N187E, C1054T, C1097A
Source :
mol_id organism_scientific expression_system
1 Homo sapiens  (taxid:9606) Spodoptera frugiperda  (taxid:7108)
gene: ADRB2, ADRB2R, B2AR / E
expression_system_vector_type: Baculovirus
expression_system_plasmid: pFastBac
Authors : Hanson, M.A., Cherezov, V., Roth, C.B., Griffith, M.T., Jaakola, V.-P., Chien, E.Y.T., Velasquez, J., Kuhn, P., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Keywords : GPCR, Membrane protein, Lysozyme, Fusion, Adrenergic, timolol, G-protein coupled receptor, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Receptor, Transducer, Transmembrane, Structural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D, GPCR Network
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

Hanson, M.A.,Cherezov, V.,Griffith, M.T.  et al.
(2008)  Structure  16 : 897 - 905

PubMed: 18547522
DOI: 10.1016/j.str.2008.05.001

Reaction

Chain : A
UniProt : P07550 (ADRB2_HUMAN)
Reaction : -
Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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