Brand  (β version)

PDB ID: 3D29

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Ligands
Code Name Style Show Link
HXD (3r)-3-hydroxydodecanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3D29   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Proteasome Inhibition by Fellutamide B
Release Data : 2008-06-10
Compound :
mol_id molecule chains
1 PRE8 isoform 1 A,O
mol_id molecule chains
2 PRE9 isoform 1 B,P
mol_id molecule chains
3 PRE6 isoform 1 C,Q
mol_id molecule chains
4 PUP2 isoform 1 D,R
mol_id molecule chains
5 PRE5 isoform 1 E,S
mol_id molecule chains
6 PRE10 isoform 1 F,T
mol_id molecule chains
7 SCL1 isoform 1 G,U
mol_id molecule chains
8 proteasome endopeptidase complex H,V
ec: 3.4.25.1
mol_id molecule chains
9 PUP3 isoform 1 I,W
mol_id molecule chains
10 Proteasome subunit beta J,X
mol_id molecule chains
11 proteasome endopeptidase complex K,Y
ec: 3.4.25.1
mol_id molecule chains
12 PRE7 isoform 1 L,Z
mol_id molecule chains
13 Proteasome subunit beta M,1
mol_id molecule chains synonym
14 Proteasome subunit beta type-1 N,2 Macropain subunit PRE3,Multicatalytic endopeptidase complex subunit PRE3,Proteasome component PRE3,Proteinase YSCE subunit PRE3
ec: 3.4.25.1
mol_id molecule chains
15 Fellutamide B a,b,c,d,e,f
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae  (taxid:4932) Brewer's yeast
strain: bakers yeast
other_details: native purification from cell lysate
mol_id organism_scientific
15 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Groll, M., Hines, J., Fahnestock, M., Crews, M.C.
Keywords : anti-parallel beta-sheet structure flanked by alpha-helices, Cytoplasm, Hydrolase, Nucleus, Protease, Proteasome, Threonine protease, Ubl conjugation, Phosphoprotein, Zymogen
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis

Hines, J.,Groll, M.,Fahnestock, M.  et al.
(2008)  Chem.Biol.  15 : 501 - 512

PubMed: 18482702
DOI: 10.1016/j.chembiol.2008.03.020

Reaction

Chain : A, O
UniProt : A0A6L1BIF8 (A0A6L1BIF8_YEASX)
Reaction : -
Chain : B, P
UniProt : A0A6A5PXC6 (A0A6A5PXC6_YEASX)
Reaction : -
Chain : C, Q
UniProt : A0A6A5Q273 (A0A6A5Q273_YEASX)
Reaction : -
Chain : D, R
UniProt : A0A6A5PXN2 (A0A6A5PXN2_YEASX)
Reaction : -
Chain : E, S
UniProt : A0A6A5PTH4 (A0A6A5PTH4_YEASX)
Reaction : -
Chain : F, T
UniProt : A0A6A5Q4M4 (A0A6A5Q4M4_YEASX)
Reaction : -
Chain : G, U
UniProt : A0A6A5PYC9 (A0A6A5PYC9_YEASX)
Reaction : -
Chain : H, V
UniProt : A0A6A5Q449 (A0A6A5Q449_YEASX)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 ARBA:ARBA00001198
-
Chain : I, W
UniProt : A0A6L0YA22 (A0A6L0YA22_YEASX)
Reaction : -
Chain : J, X
UniProt : A0A6A5Q0W2 (A0A6A5Q0W2_YEASX)
Reaction : -
Chain : K, Y
UniProt : A0A6A5Q5W3 (A0A6A5Q5W3_YEASX)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 ARBA:ARBA00001198
-
Chain : L, Z
UniProt : A0A6A5Q0P3 (A0A6A5Q0P3_YEASX)
Reaction : -
Chain : M, 1
UniProt : A0A8H8ULD3 (A0A8H8ULD3_YEASX)
Reaction : -
Chain : N, 2
UniProt : P38624 (PSB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-