Brand  (β version)

PDB ID: 3D23

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
02J 5-methyl-1,2-oxazole-3-carboxylic acid
PJE (E,4s)-4-azanyl-5-[(3s)-2-oxidanylidenepyrrolidin-3-yl]pent-2-enoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
010 Phenylmethanol

Structure summary

Code : 3D23   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Main protease of HCoV-HKU1
Release Data : 2008-09-16
Compound :
mol_id molecule chains
1 3C-like proteinase B,A,C,D
ec: 3.4.22.-
mol_id molecule chains
2 N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE H,F,E,G
Source :
mol_id organism_scientific organism_common expression_system
1 Human coronavirus  (taxid:443239) HCoV-HKU1 Escherichia coli  (taxid:562)
strain: HKU1
gene: rep
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX4T-1
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Zhao, Q., Chen, C., Li, S., Zou, Y.
Keywords : main protease, ATP-binding, Endonuclease, Exonuclease, Helicase, Membrane, Metal-binding, Nuclease, Nucleotide-binding, Nucleotidyltransferase, Protease, RNA replication, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase, Transmembrane, Zinc-finger, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.

Zhao, Q.,Li, S.,Xue, F.  et al.
(2008)  J.Virol.  82 : 8647 - 8655

PubMed: 18562531
DOI: 10.1128/JVI.00298-08

Reaction

Chain : B, A, C, D
UniProt : Q5MQD2
Reaction : -