Het-PDB Navi2 (PDB: 3CY3)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
JN5	(2s)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine

Glycosylation
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Download interaction data: 3CY3

Code :

3CY3 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V

Release Data :

2008-07-15

Compound :

mol_id	molecule	chains
1	Serine/threonine-protein kinase pim-1	A
	ec: 2.7.11.1 mutation: R250G

mol_id	molecule	chains
2	Pimtide peptide	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PIM1 expression_system_strain: BL21(DE3)-R3 expression_system_vector_type: Plasmid expression_system_plasmid: pNIC28-Bsa4

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Filippakopoulos, P., Bullock, A., Fedorov, O., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Keywords :

oncogene, kinase, serine-threonine, PIM1, Structural Genomics Consortium, SGC, Alternative initiation, ATP-binding, Manganese, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, Serine/threonine-protein kinase, Transferase, Host-virus interaction, Viral immunoevasion, Virion, Virulence

Exp. method :

X-RAY DIFFRACTION ( 2.150 Å )

Citation :

Proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V.

Filippakopoulos, P.,Bullock, A.,Fedorov, O. et al.
To be Published

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862
	-	PubMed:15525646, PubMed:15657054, PubMed:15808862

PDB ID: 3CY3

Hetero Atom Contents

Structure summary

Reaction